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In enzymology, a fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) is an enzyme that catalyzes the chemical reaction

GTP + beta-L-fucose 1-phosphate ${\displaystyle \rightleftharpoons }$ diphosphate + GDP-L-fucose

Thus, the two substrates of this enzyme are GTP and beta-L-fucose 1-phosphate, whereas its two products are diphosphate and GDP-L-fucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:beta-L-fucose-1-phosphate guanylyltransferase. Other names in common use include GDP fucose pyrophosphorylase, guanosine diphosphate L-fucose pyrophosphorylase, GDP-L-fucose pyrophosphorylase, GDP-fucose pyrophosphorylase, and GTP:L-fucose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.

References

• Ishihara H, Heath EC (1968). "The metabolism of L-fucose. IV. The biosynthesis of guanosine diphosphate L-fucose in porcine liver". J. Biol. Chem. 243 (6): 1110–5. PMID 5646162.

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