G4221 Shanghai–Wuhan Expressway (Chinese: 沪武高速公路) is an expressway in China. It starts at Shanghai, passing through Taicang, Changshu, Jiangyin, Jintan District of Changzhou, Lishui District of Nanjing, Ma'anshan, Chao Lake, Lujiang County, Yuexi County, Yingshan County and Tuanfeng County, ending in Wuhan.
Note: italic indicates the routes that were available in 2013 network plan, but removed in 2022 network plan