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GAB3
Identifiers
Aliases	GAB3, GRB2 associated binding protein 3
External IDs	OMIM: 300482; MGI: 2387324; HomoloGene: 15417; GeneCards: GAB3; OMA:GAB3 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 154,675,249 bp End 154,751,583 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A7.3 Start 74,010,449 bp End 74,129,064 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle cardiac muscle tissue of right atrium granulocyte apex of heart blood spleen monocyte gonad trabecular bone testicle Top expressed in zygote granulocyte stroma of bone marrow blood embryo secondary oocyte embryo Rostral migratory stream spleen thymus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 139716 210710 Ensembl ENSG00000160219 ENSMUSG00000032750 UniProt Q8WWW8 Q8BSM5 RefSeq (mRNA) NM_001081573 NM_001282283 NM_080612 NM_181584 RefSeq (protein) NP_001075042 NP_001269212 NP_542179 NP_853615 Location (UCSC) Chr X: 154.68 – 154.75 Mb Chr X: 74.01 – 74.13 Mb PubMed search
Wikidata
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GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene.

Function

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000160219 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032750 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 2019-08-03.

Further reading

• Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G (2002). "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Mol. Cell. Biol. 22 (11): 3744–56. doi:10.1128/mcb.22.11.3744-3756.2002. PMC 133813. PMID 11997510.
• Sliz, Anna; Locker, Kathryn C. S.; Lampe, Kristin; Godarova, Alzbeta; Plas, David R.; Janssen, Edith M.; Jones, Helen; Herr, Andrew B.; Hoebe, Kasper (2019). "Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy". Science Immunology. 4 (38): eaav3866. doi:10.1126/sciimmunol.aav3866. ISSN 2470-9468. PMC 7068803. PMID 31375526.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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