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GADD45GIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	GADD45GIP1, CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1, GADD45G interacting protein 1
External IDs	OMIM: 605162; MGI: 1914947; HomoloGene: 33474; GeneCards: GADD45GIP1; OMA:GADD45GIP1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 12,953,119 bp End 12,957,223 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C3 Start 85,558,151 bp End 85,562,111 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh mucosa of transverse colon left ventricle gastrocnemius muscle right auricle triceps brachii muscle anterior cingulate cortex olfactory zone of nasal mucosa right adrenal gland Top expressed in left lobe of liver primary oocyte digastric muscle extraocular muscle interventricular septum right ventricle temporal muscle myocardium of ventricle sternocleidomastoid muscle adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component mitochondrial matrix mitochondrial ribosome nucleus mitochondrion ribosome Biological process cell cycle mitochondrial translational elongation mitochondrial translational termination viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90480 102060 Ensembl ENSG00000179271 ENSMUSG00000033751 UniProt Q8TAE8 Q9CR59 RefSeq (mRNA) NM_052850 NM_183358 RefSeq (protein) NP_443082 NP_899202 Location (UCSC) Chr 19: 12.95 – 12.96 Mb Chr 8: 85.56 – 85.56 Mb PubMed search
Wikidata
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Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.

Interactions

GADD45GIP1 has been shown to interact with GADD45G, GADD45B and GADD45A.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000179271 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000033751 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Horikoshi N, Cong J, Kley N, Shenk T (Aug 1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochemical and Biophysical Research Communications. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
6. Görnemann J, Hofmann TG, Will H, Müller M (Nov 2002). "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins". Virology. 303 (1): 69–78. doi:10.1006/viro.2002.1670. PMID 12482659.
7. "Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1".
8. Kim SJ, Kwon Mc, Ryu MJ, Chung HK, Tadi S, Kim YK, et al. (2012). "CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane". Cell Metabolism. 16 (2): 274–283. doi:10.1016/j.cmet.2012.06.012. ISSN 1550-4131. PMID 22819524.
9. ^ Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.

Further reading

• Ahn BH, Kim TH, Bae YS (Oct 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Molecules and Cells. 12 (2): 158–63. doi:10.1016/S1016-8478(23)17077-4. PMID 11710515.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M (Jan 2005). "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation". Molecular Endocrinology. 19 (1): 12–24. doi:10.1210/me.2004-0107. PMID 15459248.
• Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS (Jan 2007). "Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation". Gene. 386 (1–2): 147–53. doi:10.1016/j.gene.2006.08.023. PMID 17069992.
• Nakayama K, Nakayama N, Wang TL, Shih Ie-M (Sep 2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Research. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.

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