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GAL3ST1
Identifiers
Aliases	GAL3ST1, CST, galactose-3-O-sulfotransferase 1
External IDs	OMIM: 602300; MGI: 1858277; HomoloGene: 3574; GeneCards: GAL3ST1; OMA:GAL3ST1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.2 Start 30,554,635 bp End 30,574,665 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A1 Start 3,933,636 bp End 3,949,326 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment tibial nerve gonad putamen duodenum nucleus accumbens Amygdala caudate nucleus substantia nigra sural nerve Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach right kidney duodenum lumbar subsegment of spinal cord anterior horn of spinal cord deep cerebellar nuclei sciatic nerve optic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity galactosylceramide sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus integral component of plasma membrane membrane Biological process glycolipid biosynthetic process myelination galactosylceramide biosynthetic process protein N-linked glycosylation spermatogenesis sphingolipid metabolic process lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9514 53897 Ensembl ENSG00000128242 ENSMUSG00000049721 UniProt Q99999 Q9JHE4 RefSeq (mRNA) NM_004861 NM_001318103 NM_001318104 NM_001318105 NM_001318106 NM_001318107 NM_001318108 NM_001318109 NM_001318110 NM_001318111 NM_001318112 NM_001318113 NM_001318114 NM_001318115 NM_001318116 NM_001177691 NM_001177703 NM_016922 NM_001382290 NM_001382291 RefSeq (protein) NP_001305032 NP_001305033 NP_001305034 NP_001305035 NP_001305036 NP_001305037 NP_001305038 NP_001305039 NP_001305040 NP_001305041 NP_001305042 NP_001305043 NP_001305044 NP_001305045 NP_004852 NP_001171162 NP_001171174 NP_058618 NP_001369219 NP_001369220 Location (UCSC) Chr 22: 30.55 – 30.57 Mb Chr 11: 3.93 – 3.95 Mb PubMed search
Wikidata
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Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000128242 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000049721 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
6. Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
7. ^ "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Further reading

• Siegrist HP, Jutzi H, Steck AJ, et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta. 489 (1): 58–63. doi:10.1016/0005-2760(77)90231-4. PMID 911873.
• Stein C, Gieselmann V, Kreysing J, et al. (1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. doi:10.1016/S0021-9258(19)85079-2. PMID 2562955.
• Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
• Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. doi:10.1016/S0021-9258(18)61991-X. PMID 5562350.
• Costantino-Ceccarini E, Waehneldt TV, Ginalski H, et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086. S2CID 32069166.
• Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451. S2CID 23693243.
• Honke K, Yamane M, Ishii A, et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034.
• Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. doi:10.1046/j.1432-1327.2000.01281.x. PMID 10785389.
• Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMC 1222978. PMID 12175333.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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