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GPC5
Identifiers
Aliases	GPC5, glypican 5
External IDs	OMIM: 602446; MGI: 1194894; HomoloGene: 3285; GeneCards: GPC5; OMA:GPC5 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q31.3 Start 91,398,621 bp End 92,873,682 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 E4 Start 115,329,647 bp End 116,762,591 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle caudate nucleus putamen endothelial cell nucleus accumbens entorhinal cortex Pons superior vestibular nucleus Amygdala external globus pallidus Top expressed in substantia nigra globus pallidus deep cerebellar nuclei dorsal tegmental nucleus otolith organ utricle paraventricular nucleus of hypothalamus lateral hypothalamus inferior colliculi medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparan sulfate proteoglycan binding Cellular component integral component of plasma membrane extracellular region membrane anchored component of membrane Golgi lumen plasma membrane lysosomal lumen extracellular space anchored component of plasma membrane integral component of membrane collagen-containing extracellular matrix cell surface Biological process glycosaminoglycan biosynthetic process retinoid metabolic process glycosaminoglycan catabolic process regulation of signal transduction cell migration positive regulation of canonical Wnt signaling pathway regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2262 103978 Ensembl ENSG00000179399 ENSMUSG00000022112 UniProt P78333 Q8CAL5 RefSeq (mRNA) NM_004466 NM_175500 RefSeq (protein) NP_004457 NP_780709 Location (UCSC) Chr 13: 91.4 – 92.87 Mb Chr 14: 115.33 – 116.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Glypican-5 is a protein that in humans is encoded by the GPC5 gene.

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

See also

• Glypican

References

1. ^ GRCh38: Ensembl release 89: ENSG00000179399 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022112 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G (Jun 1997). "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family". Genomics. 40 (1): 24–30. doi:10.1006/geno.1996.4518. PMID 9070915.
6. ^ "Entrez Gene: GPC5 glypican 5".

Further reading

• De Cat B, David G (2001). "Developmental roles of the glypicans". Semin. Cell Dev. Biol. 12 (2): 117–25. doi:10.1006/scdb.2000.0240. PMID 11292377.
• Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". J. Cell Biol. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.
• Saunders S, Paine-Saunders S, Lander AD (1997). "Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain" (PDF). Dev. Biol. 190 (1): 78–93. doi:10.1006/dbio.1997.8690. PMID 9331333. S2CID 25320509.
• Veugelers M, De Cat B, Delande N, et al. (2002). "A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32". Matrix Biol. 20 (5–6): 375–85. doi:10.1016/S0945-053X(01)00143-3. PMID 11566272.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Inoue J, Imoto I, et al. (2004). "GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines". J. Hum. Genet. 48 (6): 331–5. doi:10.1007/s10038-003-0026-2. PMID 12721791.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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