GPE may refer to:
Computing
- Geopolitical entity, a geographical area which is associated with some sort of political structure, used in named-entity recognition
- GPE Palmtop Environment, a graphical user interface
- Google Play edition, a series of consumer mobile devices
- Google Plugin for Eclipse, a set of software development tools
Science
- Gravitational potential energy
- External globus pallidus (GPe)
- Gross–Pitaevskii equation, in quantum physics
- GYPE, a protein
Other uses
- European Grand Prix for Choral Singing
- General Precision Equipment, a former American manufacturing company
- Ghanaian Pidgin English
- Global Partnership for Education
- Global Peace Exchange, at Florida State University
- Global political economy
- GP Express Airlines, an American airline
- Grand Paris Express, an extension of the Paris metro network.
- Guadeloupe national football team
- General physical education; see adapted physical education
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