GPHS can mean:
Schools
Australia:
- Glenmore Park High School, a co-educational, comprehensive government high school in Glenmore Park, New South Wales
Canada:
- Grant Park High School, in Winnipeg, Manitoba, Canada
The Philippines:
- Gregorio Perfecto High School, in Manila, Philippines
United States:
- Gage Park High School, in Chicago, Illinois
- Galena Park High School in Galena Park, Texas (Houston area)
- Gatlinburg-Pittman High School, in Gatlinburg, Tennessee
- Glacier Peak High School, in Snohomish, Washington
- Gwynn Park High School, in Brandywine CDP, Prince George's County, Maryland (Washington, DC area)
Other
- General Purpose Heat Source, a radioisotope source used in space power generation
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