GPO may refer to:
Government and politics
- General Post Office, Dublin
- General Post Office, in Britain
- Social Security Government Pension Offset, a provision reducing benefits
- Government Pharmaceutical Organization, a Thai state enterprise
- Government Press Office (Israel)
- Green Party of Ontario, Canada
- United States Government Publishing Office
- Group Purchasing Organization
Places
- Gospel Oak railway station, in London, England
- Guam Premier Outlets, a shopping mall in Guam
- Indore G.P.O., a residential area in Indore, India
- General Pico Airport, in Argentina, IATA code
Science and technology
- Giant Pacific Octopus
- Group Policy Object
- General Purpose Outlet, mains socket in Australia
- General Purpose Output, an uncommitted digital signal pin on an integrated circuit or electronic circuit board used as an output and controllable by the user at runtime.
Other uses
- Generalplan Ost, a Nazi genocide plan in occupied territories
- General Post Office (disambiguation)
- Group purchasing organization
- Gun Position Officer, usually a lieutenant, responsible for the technical control of an artillery battery in the United Kingdom and Commonwealth forces
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- Grand Piece Online, a Roblox videogame based on One Piece