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GRIPAP1
Identifiers
Aliases	GRIPAP1, GRASP-1, GRIP1 associated protein 1
External IDs	OMIM: 300408; MGI: 1859616; HomoloGene: 41348; GeneCards: GRIPAP1; OMA:GRIPAP1 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.23 Start 48,973,720 bp End 49,002,264 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.1|X 3.51 cM Start 7,656,004 bp End 7,686,806 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe sural nerve anterior pituitary cingulate gyrus anterior cingulate cortex Brodmann area 9 prefrontal cortex granulocyte Hypothalamus Top expressed in granulocyte neural layer of retina superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex yolk sac nucleus of stria terminalis ventricular zone central gray substance of midbrain More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component endosome blood microparticle nucleoplasm cytosol intracellular membrane-bounded organelle postsynaptic recycling endosome membrane cell junction axon dendrite early endosome membrane cell projection synapse recycling endosome membrane glutamatergic synapse extrinsic component of postsynaptic early endosome membrane Biological process neurotransmitter receptor transport, endosome to postsynaptic membrane regulation of modification of synaptic structure transport protein transport biological process regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane regulation of recycling endosome localization within postsynapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56850 54645 Ensembl ENSG00000068400 ENSMUSG00000031153 UniProt Q4V328 Q8VD04 RefSeq (mRNA) NM_020137 NM_207672 NM_001290455 NM_207670 NM_001359289 NM_001359290 NM_001359291 NM_001359293 RefSeq (protein) NP_064522 NP_001277384 NP_997553 NP_001346218 NP_001346219 NP_001346220 NP_001346222 Location (UCSC) Chr X: 48.97 – 49 Mb Chr X: 7.66 – 7.69 Mb PubMed search
Wikidata
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GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.

Function

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).

Interactions

GRIPAP1 has been shown to interact with GRIP1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000068400 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031153 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.
6. ^ "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

Further reading

• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP (2002). "Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex". J. Biol. Chem. 277 (4): 2396–405. doi:10.1074/jbc.M106312200. PMID 11704662.
• Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. hdl:2262/89271. PMID 11891216.
• Ye B, Sugo N, Hurn PD, Huganir RL (2002). "Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody". Neuroscience. 114 (1): 217–27. doi:10.1016/S0306-4522(02)00142-2. PMID 12207967. S2CID 39432674.
• Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
• Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes Cells. 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Stinton LM, Selak S, Fritzler MJ (2005). "Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes". Clin. Immunol. 116 (2): 108–17. doi:10.1016/j.clim.2005.03.021. PMID 15897011.

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