GRS may refer to:
Politics
Malaysia
- Gabungan Rakyat Sabah (GRS), a political coalition based in Sabah, Malaysia
- Gagasan Rakyat Sabah (also known as PGRS), a political party based in Sabah, Malaysia and also a main component party of Gabungan Rakyat Sabah (GRS) coalition.
Education
- Geneva Reformed Seminary, in Greenville, South Carolina
- Gifted Rating Scales, an educational assessment test
- Great River Charter Montessori School, in St. Paul, Minnesota
Science
- Gamma-ray spectrometer
- Gamma Ray Spectrometer (2001 Mars Odyssey), an instrument on 2001 Mars Odyssey
- Genetic risk score
- Great Red Spot, a feature on Jupiter
Military
- Global Response Staff, a security role in CIA's Directorate of Support branch
- Graves Registration Service, now Mortuary Affairs, a service of the United States Army
Other uses
- General Railway Signal, a former American railway signaling company
- Gender-affirming surgery, also known as gender reassignment surgery
- The Gerry Ryan Show, an Irish radio show
- Global Resource Serialization, part of the IBM z/OS operating system
- Government Rubber-Styrene (GR-S) produced by the United States Synthetic Rubber Program during World War II
- Grand Rapids Symphony, in Michigan
- Grassroot Soccer, an international health organization
- Gresi language
- Grosseto Air Base, in Italy
- Guilford Rail System, now known as Pan Am Railways, an American railway holding company
- GRS Riflestocks, a Norwegian firearm stock manufacturer
- Gauche républicaine et socialiste, French political party
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