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GSDMB
Identifiers
Aliases	GSDMB, GSDML, PRO2521, PP4052, gasdermin B, GSDMB-1
External IDs	OMIM: 611221; HomoloGene: 88856; GeneCards: GSDMB; OMA:GSDMB - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.1 Start 39,904,595 bp End 39,919,854 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum right lobe of liver mucosa of transverse colon granulocyte mucosa of ileum duodenum cerebellar hemisphere right hemisphere of cerebellum jejunal mucosa body of stomach n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function phosphatidylserine binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-4-phosphate binding Cellular component cytoplasm cytosol plasma membrane membrane cellular component Biological process programmed cell death biological process pyroptosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55876 n/a Ensembl ENSG00000073605 n/a UniProt Q8TAX9 n/a RefSeq (mRNA) NM_001042471 NM_001165958 NM_001165959 NM_018530 NM_001369402 n/a RefSeq (protein) NP_001035936 NP_001159430 NP_001159431 NP_061000 NP_001356331 n/a Location (UCSC) Chr 17: 39.9 – 39.92 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Gasdermin B is a protein that in humans is encoded by the GSDMB gene.

Function

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.

Clinical significance

GSDMB expression has been linked to higher survival rates for lung cancer patients.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000073605 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Gasdermin B". Retrieved 2016-08-26.
4. "MCM team has been researching GSDMB". World Community Grid. 12 July 2023. Retrieved 20 September 2024.

Further reading

• Katoh M, Katoh M (2004). "Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". Int. J. Oncol. 24 (4): 757–63. doi:10.3892/ijo.24.4.757. PMID 15010812.

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• Genes on human chromosome 17
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