Guo or GUO may refer to:
People
- Guo (郭), a Chinese surname
- Consort Guo (disambiguation)
- Empress Guo (disambiguation)
- Prince Guo
Places
- Guo Prefecture (disambiguation)
- Eastern Guo, an ancient Chinese state
- Western Guo, an ancient Chinese state, divided into Northern Guo and Southern Guo
Other uses
- Guayabero language, a Guahiban language of Colombia
- Gualaco Airport, in Honduras
- Main Guard Directorate (Russian: Glavnoye upravleniye okhraneniya), a branch of the Soviet Union's KGB
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