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Galifianakis (Greek: Γαλιφιανάκης) is a Greek surname of a family originating in the Heraklion (Ηράκλειο) region of Crete, Greece. Notable people with the name include:

• Nick Galifianakis (politician) (1928–2023), American politician and Democratic U.S. Congressman from North Carolina between 1967 and 1973, uncle of Zach
• Nick Galifianakis (cartoonist) (born 1962), American cartoonist and artist who draws satirical cartoons, first cousin of Zach
• Zach Galifianakis (born 1969), American actor, comedian and writer
• Alexander Galifianakis (physician) (born 1976), American musculoskeletal radiologist, retired Navy, former Commandant of Uniformed Services University, Bethesda, MD

• Surnames
• Greek-language surnames