Geranylfarnesyl diphosphate synthase

Geranylfarnesyl diphosphate synthase (EC 2.5.1.81, FGPP synthase, (all-E) geranylfarnesyl diphosphate synthase, GFPS, Fgs) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit). This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + isopentenyl diphosphate

\rightleftharpoons

(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate

The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine.

References

Ogawa T, Yoshimura T, Hemmi H (February 2010). "Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution". Biochemical and Biophysical Research Communications. 393 (1): 16–20. doi:10.1016/j.bbrc.2010.01.063. PMID 20097171.
Tachibana A, Yano Y, Otani S, Nomura N, Sako Y, Taniguchi M (January 2000). "Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity". European Journal of Biochemistry. 267 (2): 321–8. doi:10.1046/j.1432-1327.2000.00967.x. PMID 10632701.
Tachibana A (March 1994). "A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis". FEBS Letters. 341 (2–3): 291–4. doi:10.1016/0014-5793(94)80475-3. PMID 8137956.
Lee PC, Mijts BN, Petri R, Watts KT, Schmidt-Dannert C (November 2004). "Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Engineering, Design & Selection. 17 (11): 771–7. doi:10.1093/protein/gzh089. PMID 15548566.

External links

Geranylfarnesyl+diphosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Transferases: alkyl and aryl (EC 2.5)
2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 2.5.1