Get Up and Go may refer to:
- A song first recorded by The Weavers and then Pete Seeger
- A song by Cinerama on Torino (album)
- A song by the Go-Go's on Vacation (The Go-Go's album)
- A song by The Rutles
- Get Up and Go!, a 1981–1983 British children's television series
- Another name for the Timed Up and Go test, a medical test used to evaluate a patient's abilities to perform activities of daily living
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