Giuffrida is an Italian surname. Notable people with the surname include:
- Alfio Giuffrida (born 1953), Italian sculptor
- Filippo Giuffrida Répaci (born 1964) Italian journalist, director of the magazine La Lettre b
- Giuseppe De Felice Giuffrida (1859–1920), Italian socialist politician and journalist
- Louis O. Giuffrida (1920–2012), first director of the Federal Emergency Management Agency from 1981 to 1985
- Odette Giuffrida (born 1994), Italian judoka
See also
- Giuffrida metro station, located in Catania in Sicily, southern Italy
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