Misplaced Pages

GMC oxidoreductase
Crystal structure of cholesterol oxidase complexed with a steroid substrate. Implications for FAD dependent alcohol oxidases.
Identifiers
Symbol	GMC_oxred_N
Pfam	PF00732
Pfam clan	CL0063
InterPro	IPR000172
PROSITE	PDOC00543
SCOP2	1gal / SCOPe / SUPFAM
OPM superfamily	132
OPM protein	1b4v
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

GMC oxidoreductase
Crystal structure of cholesterol oxidase complexed with a steroid substrate. Implications for fad dependent alcohol oxidases.
Identifiers
Symbol	GMC_oxred_C
Pfam	PF05199
InterPro	IPR007867
PROSITE	PDOC00543
SCOP2	1gal / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the glucose-methanol-choline oxidoreductase family (GMC oxidoreductase) is a family of enzymes with oxidoreductase activity.

The glucose-methanol-choline (GMC) oxidoreductases are FAD flavoproteins oxidoreductases. These enzymes include a variety of proteins; choline dehydrogenase (CHD) EC 1.1.99.1, methanol oxidase (MOX) EC 1.1.3.13 and cellobiose dehydrogenase EC 1.1.99.18 which share a number of regions of sequence similarities. They contain two conserved protein domains. The N-terminal domain corresponds to the FAD ADP-binding domain, the C-terminal domain is a steroid-binding domain.

References

1. Cavener DR (February 1992). "GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities". J. Mol. Biol. 223 (3): 811–4. doi:10.1016/0022-2836(92)90992-S. PMID 1542121.
2. Li J, Vrielink A, Brick P, Blow DM (November 1993). "Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases". Biochemistry. 32 (43): 11507–15. doi:10.1021/bi00094a006. PMID 8218217.
3. Henriksson G, Johansson G, Pettersson G (March 2000). "A critical review of cellobiose dehydrogenases". J. Biotechnol. 78 (2): 93–113. doi:10.1016/S0168-1656(00)00206-6. PMID 10725534.
4. Bannwarth M, Bastian S, Heckmann-Pohl D, Giffhorn F, Schulz GE (2004). "Crystal structure of pyranose 2-oxidase from the white-rot fungus Peniophora sp". Biochemistry. 43 (37): 11683–90. doi:10.1021/bi048609q. PMID 15362852.
5. Vrielink A, Lloyd LF, Blow DM (1991). "Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 A resolution". J Mol Biol. 219 (3): 533–54. doi:10.1016/0022-2836(91)90192-9. PMID 2051487.

• Protein domains