Guille is both a surname and a given name. Notable people with the name include:
Surname
- Cédric Guille (born 1978), French artistic gymnast
- Derek Guille (born 1951), Australian radio presenter
- John Guille (born 1949), British Anglican priest
Given name
- Guille Garcia (born 1947), Cuban-born American musician
- Guille López (born 1992), Spanish footballer
- Guille Rubio (born 1982), Spanish basketball player
- Guille Smitarello (born 1993), Spanish footballer
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