Guillermo Gonzalez may refer to:
- Guillermo Gonzalez (soccer) (born 1986), American soccer player
- Guillermo Gonzalez (astronomer) (born 1963), Cuban astrophysicist and promoter of intelligent design
- Guillermo González Camarena (1917–1965), Mexican engineer who was an inventor of modern color television
- Guillermo González (athlete) (born 1950), Dominican athlete
- Guillermo Gonzalez (pianist), Spanish classical pianist
- Guillermo González del Río García (1912–1984), Spanish footballer
- Guillermo González (politician), Colombian politician
See also
- Guillermo Gonzales (born 1976), Italian singer, songwriter and musician
- Guillermo Gozálvez (born 2003), Argentine footballer
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