Guillory is a surname. Notable people with the surname include:
- Anthony Guillory (1942–2021), American football linebacker
- Curtis Guillory, American bishop
- Elbert Guillory (born 1944), Louisiana politician
- Isaac Guillory (1947–2000), American folk guitarist
- Jahking Guillory, American actor
- John Guillory (born 1952), American literary critic
- John Guillory (born 1945), former American football player
- Lorilei Guillory, subject of the 2003 play Lorilei
- Matt Guillory (born 1974), American musician
- Sienna Guillory (born 1975), English actress and model
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