Guthridge is a surname. Notable people with the surname include:
- Bill Guthridge (1937–2015), American basketball player and coach
- George Guthridge (born 1948), American writer
- Nehemiah Guthridge (1812–1878), Australian businessman
- Richard Charles Guthridge (1837–1934), Australian merchant seaman and farmer
See also
- Lake Guthridge, lake in Sale, Victoria, Australia
- Guthridge Nunataks, nunataks of Antarctica
- Guthridge, Missouri, a community in the United States
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