Guzik is a Polish surname meaning "button". Notable people with the surname include:
- Alberto Guzik (1944-2010), Brazilian actor
- Anna Guzik (born 1976), Polish actress
- Grzegorz Guzik (born 1991), Polish biathlete
- Jake Guzik (1886-1956), American mobster
- John Guzik (linebacker) (1936-2012), American football player
- John Guzik (defensive lineman) (born 1962), American football player
- Jolanta Guzik (born 1981), Polish chess master
- Martin Guzik (born 1974), Czech footballer
- Tomasz Guzik (born 1974), Polish scientist
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