| gyrA RNA motif | |
|---|---|
 Consensus secondary structure of gyrA RNAs | |
| Identifiers | |
| Symbol | gyrA RNA |
| Rfam | RF01740 |
| Other data | |
| RNA type | Cis-regulatory element |
| Domain(s) | Pseudomonadales |
| PDB structures | PDBe |
The gyrA RNA motif is a conserved RNA structure identified by bioinformatics. The RNAs are present in multiple species of bacteria within the order Pseudomonadales. This order contains the genus Pseudomonas, which includes the opportunistic human pathogen Pseudomonas aeruginosa and Pseudomonas syringae, a plant pathogen.
gyrA RNAs are always found in the presumed 5' untranslated regions of gyrA genes, which encodes a protein forming a subunit of a DNA gyrase. Resistance to the antibiotic ciprofloxacin in Pseudomonas is often achieved via mutations in the gyrA gene. Because of its positioning, the gyrA RNA motif was hypothesized to be a cis-regulatory element acting up the downstream gyrA genes. However, gyrA was previously regarded as a gene whose level of expression is consistent in a wide variety of growth conditions.
References
- Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol. 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC 2864571. PMID 20230605.
- Bonomo RA, Szabo D (September 2006). "Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa". Clin. Infect. Dis. 43 (Suppl 2): S49–56. doi:10.1086/504477. PMID 16894515.
- Vencato M, Tian F, Alfano JR, et al. (November 2006). "Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A". Mol. Plant Microbe Interact. 19 (11): 1193–1206. doi:10.1094/MPMI-19-1193. PMID 17073302.
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