H100 or H-100 may refer to:
- H100, Nvidia GPU
- H.100 (computer telephony), a standard for communication between PCI cards in a computer telephony system
- H100 series, a diesel multiple unit train in Japan
- Heathkit H100, a kit by Heathkit sold assembled as the Zenith Z-100 computer
- Hyundai Grace, a minibus or van
- Hyundai Porter, a pickup truck
- iRiver H100 series, a series of hard drive digital audio players produced by iriver
- The fourth generation of Toyota HiAce, also known as H100
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