HDC may refer to:
Computing
- Hyperdimensional computing, with very long vectors
- Handle of Device Context, part of the GDI API
- High-Definition Coding, an audio codec
- /dev/hdc; a Unix-like ATA device file
Law
- Holder in due course, in commercial law
- Home Detention Curfew, United Kingdom
Music
- Heavyweight Dub Champion, an American electronic group
- Herräng Dance Camp, Sweden
Organizations
- Halal Industry Development Corporation, Malaysia
- Health and Disability Commissioner, New Zealand
- Health Data Consortium, US
- Historic Districts Council, New York City, US
- Honeysuckle Development Corporation, NSW, Australia
- HDC Hyundai Development Company, South Korea
Transportation
- Haldia Dock Complex, of the Port of Kolkata, India
- Hammond Northshore Regional Airport (FAA LID code), Louisiana, US
- Hill descent control system, of an automobile
Other uses
- Histidine decarboxylase, an enzyme
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