Misplaced Pages

HECTD4
Identifiers
Aliases	HECTD4, C12orf51, POTAGE, HECT domain E3 ubiquitin protein ligase 4, HEEL, C12ord51
External IDs	MGI: 3647820; HomoloGene: 28297; GeneCards: HECTD4; OMA:HECTD4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.13 Start 112,160,188 bp End 112,382,439 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 121,358,282 bp End 121,506,640 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum middle temporal gyrus ganglionic eminence Brodmann area 23 paraflocculus of cerebellum cerebellar vermis right frontal lobe primary visual cortex Brodmann area 9 prefrontal cortex Top expressed in superior cervical ganglion medial dorsal nucleus visual cortex subiculum piriform cortex central gray substance of midbrain medial geniculate nucleus primary visual cortex superior colliculus inferior colliculi More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity ubiquitin-protein transferase activity ubiquitin protein ligase activity Cellular component integral component of membrane membrane cytoplasm Biological process protein ubiquitination glucose homeostasis glucose metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283450 269700 Ensembl ENSG00000173064 ENSMUSG00000042744 UniProt Q9Y4D8 n/a RefSeq (mRNA) NM_173813 NM_001109662 NM_001388303 NM_181421 RefSeq (protein) NP_001103132 n/a Location (UCSC) Chr 12: 112.16 – 112.38 Mb Chr 5: 121.36 – 121.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

HECT domain E3 ubiquitin protein ligase 4 is a protein that in humans is encoded by the HECTD4 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000173064 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000042744 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HECT domain E3 ubiquitin protein ligase 4". Retrieved 2016-10-24.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Go MJ, Hwang JY, Kim YJ, Hee Oh J, Kim YJ, Heon Kwak S, Soo Park K, Lee J, Kim BJ, Han BG, Cho MC, Cho YS, Lee JY (2013). "New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population". J. Hum. Genet. 58 (6): 362–5. doi:10.1038/jhg.2013.14. PMID 23575436.

This article on a gene on human chromosome 12 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 12
• Human chromosome 12 gene stubs