HLA-A19 (A19) is a human leukocyte antigen HLA-A serotype that may recognize the A29, A30, A31, A32, A33, and A74 serotypes. While these haplotypes are found all over the globe, their combined frequencies are higher in Sub Saharan Africa; frequencies tend to decline away from Africa.
Clinical significance
HLA-A19 has been implicated in a number of diseases, including renal cell carcinoma, Kaposi's sarcoma, vitiligo, and others; antibodies to HLA-A19 were recorded in 86% of infertile men and 92% of infertile women.
| Split antigen serotypes of A19 HLA-A |
| HLA-A29 |
| HLA-A30 |
| HLA-A31 |
| HLA-A32 |
| HLA-A33 |
| HLA-A74 |
References
- ^ Shankarkumar, Umapathy; Ghosh, Kanjaksha; Mohanty, Dipika (September 2002). "Defining the allelic variants of HLA A19 in the western Indian population". Human Immunology. 63 (9): 779–782. doi:10.1016/S0198-8859(02)00424-X.
- Genco, Petrina V.; Mathur, Subbi; Oliver Williamson, H.; Rust, Philip F.; Glassman, Armand B.; Hugh Fudenberg, H. (1984-10-01). "Antibodies to A19 and Bw35 complexes of human leukocyte antigens are present in infertile subjects with sperm antibodies*†‡". Fertility and Sterility. 42 (4): 554–560. doi:10.1016/S0015-0282(16)48138-0. ISSN 0015-0282.
| HLA-A serotypes | |
|---|---|