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HLA-DQ9

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HLA-DQ9
Illustration of HLA-DQ with bound peptide.
Polymer typeMHC Class II, DQ cell surface antigen
Cis-haplotype Haplotype
isoform subtype DQA1 DQB1
DQ αβ DQ9.2 *0201 *0303
DQ αβ DQ9.3 *0302 *0303

HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. DQ9 is determined by the antibody recognition of β and this generally detects the gene product of DQB1*0303.

Serology

DQ2, DQ3, DQ7, DQ8, and DQ9 recognition of DRB1*0303 product
DQ9 DQ3 DQ2 DQ7 DQ8 sample
% % % % % (N)
*0303 67 12 11 1 1 2563
Red indicates the level of 'false' reaction in non-DQ9 serotypes
Alleles link-out to IMGT/HLA Databease at EBI

The serotyping efficiency of DQ9 is poor. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB1*0303 as efficiently as DQ3. For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.

DQB1*0303

(DQ9) is associated with nasal polyps, gestational diabetes, microscopic polyangiitis (Japanese). Primary linkage is with DRB1*0901-DQB1*0303

Haplotypes and disease

DQ9.2

DQA1*0201:DQB1*0303 is associated with type I psoriasis (vulgaris),

DQ9.3

DQA1*0302:DQB1*0303 maybe associated with juvenile diabetes in the orient. (Chinese) Primary linkage of vitiligo is with DQA1*03-DQB1*0303.

References

  1. derived from IMGT/HLA
  2. Zhai L, Sun Y, Tang L, Liu H (2007). "Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps". Ann. Otol. Rhinol. Laryngol. 116 (1): 66–8. doi:10.1177/000348940711600111. PMID 17305280. S2CID 31676125.
  3. Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population". Hum. Immunol. 65 (12): 1443–50. doi:10.1016/j.humimm.2004.09.002. PMID 15603871.
  4. Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (2006). "Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese". Genes Immun. 7 (1): 81–4. doi:10.1038/sj.gene.6364262. PMID 16208405. S2CID 44812261.
  5. Schmitt-Egenolf M, Boehncke WH, Ständer M, Eiermann TH, Sterry W (1993). "Oligonucleotide typing reveals association of type I psoriasis with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 extended haplotype". J. Invest. Dermatol. 100 (6): 749–52. doi:10.1111/1523-1747.ep12476080. PMID 8496614.
  6. Zhang X, Wei S, Yang S, et al. (2004). "HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han". Int. J. Dermatol. 43 (3): 181–7. doi:10.1111/j.1365-4632.2004.02098.x. PMID 15009387. S2CID 36893870.
  7. Maruyama T, Shimada A, Kasuga A, et al. (1994). "Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay". Diabetes Res. Clin. Pract. 23 (2): 77–84. doi:10.1016/0168-8227(94)90014-0. PMID 8070305.
  8. Ikegami H, Kawaguchi Y, Yamato E, et al. (1992). "Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus". J. Clin. Endocrinol. Metab. 75 (5): 1381–5. doi:10.1210/jcem.75.5.1358911. PMID 1358911.
  9. Xia Q, Zhou WM, Liang YH, et al. (2006). "MHC haplotypic association in Chinese Han patients with vitiligo". Journal of the European Academy of Dermatology and Venereology. 20 (8): 941–6. doi:10.1111/j.1468-3083.2006.01686.x. PMID 16922942. S2CID 12831704.
HLA-DQ
Genetic loci
Serotypes
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