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HNRNPD
Available structures PDB Ortholog search: D6RF44 PDBe D6RF44 RCSB List of PDB id codes 1HD0, 1HD1, 1IQT, 1WTB, 1X0F, 2Z5N
Identifiers
Aliases	HNRNPD, AUF1, AUF1A, HNRPD, P37, hnRNPD0, heterogeneous nuclear ribonucleoprotein D
External IDs	OMIM: 601324; MGI: 101947; HomoloGene: 22410; GeneCards: HNRNPD; OMA:HNRNPD - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.22 Start 82,352,498 bp End 82,374,503 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E4 Start 100,103,794 bp End 100,126,797 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone epithelium of nasopharynx tendon of biceps brachii pylorus endometrium gingival epithelium lactiferous duct germinal epithelium tonsil Top expressed in tail of embryo genital tubercle epiblast ventricular zone mandibular prominence maxillary prominence neural layer of retina abdominal wall ganglionic eminence somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function telomeric DNA binding protein binding minor groove of adenine-thymine-rich DNA binding mRNA binding histone deacetylase binding transcription factor binding chromatin binding mRNA 3'-UTR AU-rich region binding DNA binding nucleic acid binding RNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component cytoplasm cytosol extracellular exosome nucleoplasm nucleus synapse ribonucleoprotein complex Biological process response to electrical stimulus hepatocyte dedifferentiation cellular response to amino acid stimulus positive regulation of transcription, DNA-templated response to estradiol mRNA stabilization response to rapamycin cellular response to putrescine cerebellum development negative regulation of gene expression mRNA splicing, via spliceosome positive regulation of translation RNA processing liver development transcription, DNA-templated regulation of circadian rhythm response to calcium ion response to sodium phosphate 3'-UTR-mediated mRNA destabilization regulation of mRNA stability cellular response to nitric oxide rhythmic process cellular response to estradiol stimulus brain development RNA catabolic process circadian regulation of translation regulation of transcription, DNA-templated positive regulation of gene expression mRNA transcription by RNA polymerase II positive regulation of telomere capping positive regulation of telomerase RNA reverse transcriptase activity regulation of telomere maintenance RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3184 11991 Ensembl ENSG00000138668 ENSMUSG00000000568 UniProt Q14103 Q60668 RefSeq (mRNA) NM_031370 NM_001003810 NM_002138 NM_031369 NM_001077265 NM_001077266 NM_001077267 NM_007516 RefSeq (protein) NP_001003810 NP_002129 NP_112737 NP_112738 NP_001070733 NP_001070734 NP_001070735 NP_031542 Location (UCSC) Chr 4: 82.35 – 82.37 Mb Chr 5: 100.1 – 100.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the HNRNPD gene. Alternative splicing of this gene results in four transcript variants.

Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). The interaction sites on the RNA are frequently biased towards particular sequence motifs. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability.

Interactions

HnRNP D has been shown to interact with SAFB and Hsp27. It also has been reported to interact with mRNAs such as Mef2c mRNA.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000138668 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000000568 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dempsey LA, Li MJ, DePace A, Bray-Ward P, Maizels N (August 1998). "The human HNRPD locus maps to 4q21 and encodes a highly conserved protein". Genomics. 49 (3): 378–384. doi:10.1006/geno.1998.5237. PMID 9615222.
6. ^ "Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)".
7. Mazan-Mamczarz K, Kuwano Y, Zhan M, White EJ, Martindale JL, Lal A, Gorospe M (January 2009). "Identification of a signature motif in target mRNAs of RNA-binding protein AUF1". Nucleic Acids Research. 37 (1): 204–14. doi:10.1093/nar/gkn929. PMC 2615618. PMID 19033365.
8. Arao Y, Kuriyama R, Kayama F, Kato S (August 2000). "A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D". Arch. Biochem. Biophys. 380 (2): 228–36. doi:10.1006/abbi.2000.1938. PMID 10933876.
9. Sinsimer KS, Gratacós FM, Knapinska AM, Lu J, Krause CD, Wierzbowski AV, Maher LR, Scrudato S, Rivera YM, Gupta S, Turrin DK, De La Cruz MP, Pestka S, Brewer G (September 2008). "Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay". Mol. Cell. Biol. 28 (17): 5223–37. doi:10.1128/MCB.00431-08. PMC 2519747. PMID 18573886.
10. Panda AC, Abdelmohsen K, Yoon JH, Martindale JL, Yang X, Curtis J, Mercken EM, Chenette DM, Zhang Y, Schneider RJ, Becker KG, de Cabo R, Gorospe M (August 2014). "RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels". Mol Cell Biol. 34 (16): 3106–19. doi:10.1128/MCB.00423-14. PMC 4135590. PMID 24891619.

Further reading

• Tay N, Chan SH, Ren EC (1992). "Identification and cloning of a novel heterogeneous nuclear ribonucleoprotein C-like protein that functions as a transcriptional activator of the hepatitis B virus enhancer II". J. Virol. 66 (12): 6841–8. doi:10.1128/JVI.66.12.6841-6848.1992. PMC 240284. PMID 1433497.
• Lahiri DK, Thomas JO (1986). "A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2". Nucleic Acids Res. 14 (10): 4077–4094. doi:10.1093/nar/14.10.4077. PMC 339847. PMID 3754960.
• Kajita Y, Nakayama J, Aizawa M, Ishikawa F (1995). "The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family". J. Biol. Chem. 270 (38): 22167–75. doi:10.1074/jbc.270.38.22167. PMID 7673195.
• Zhang W, Wagner BJ, Ehrenman K, Schaefer AW, DeMaria CT, Crater D, DeHaven K, Long L, Brewer G (December 1993). "Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1". Mol. Cell. Biol. 13 (12): 7652–65. doi:10.1128/MCB.13.12.7652. PMC 364837. PMID 8246982.
• Wagner BJ, Long L, Rao PN, Pettenati MJ, Brewer G (June 1996). "Localization and physical mapping of genes encoding the A+U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X". Genomics. 34 (2): 219–22. doi:10.1006/geno.1996.0269. PMID 8661052.
• Kiledjian M, DeMaria CT, Brewer G, Novick K (1997). "Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex". Mol. Cell. Biol. 17 (8): 4870–6. doi:10.1128/MCB.17.8.4870. PMC 232339. PMID 9234743.
• Wagner BJ, DeMaria CT, Sun Y, Wilson GM, Brewer G (March 1998). "Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms". Genomics. 48 (2): 195–202. doi:10.1006/geno.1997.5142. PMID 9521873.
• Siomi MC, Fromont M, Rain JC, Wan L, Wang F, Legrain P, Dreyfuss G (July 1998). "Functional conservation of the transportin nuclear import pathway in divergent organisms". Mol. Cell. Biol. 18 (7): 4141–8. doi:10.1128/MCB.18.7.4141. PMC 108998. PMID 9632798.
• Tolnay M, Vereshchagina LA, Tsokos GC (1999). "Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein". Biochem. J. 338 (2): 417–25. doi:10.1042/0264-6021:3380417. PMC 1220068. PMID 10024518.
• Nagata T, Kurihara Y, Matsuda G, Saeki J, Kohno T, Yanagida Y, Ishikawa F, Uesugi S, Katahira M (March 1999). "Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0". J. Mol. Biol. 287 (2): 221–37. doi:10.1006/jmbi.1999.2616. PMID 10080887.
• Laroia G, Cuesta R, Brewer G, Schneider RJ (1999). "Control of mRNA decay by heat shock-ubiquitin-proteasome pathway". Science. 284 (5413): 499–502. Bibcode:1999Sci...284..499L. doi:10.1126/science.284.5413.499. PMID 10205060.
• Blaxall BC, Dwyer-Nield LD, Bauer AK, Bohlmeyer TJ, Malkinson AM, Port JD (June 2000). "Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue". Mol. Carcinog. 28 (2): 76–83. doi:10.1002/1098-2744(200006)28:2<76::AID-MC3>3.0.CO;2-0. PMID 10900464. S2CID 25180996.
• Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (January 2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". Biol. Chem. 384 (1): 25–37. doi:10.1515/BC.2003.004. PMID 12674497. S2CID 30993043.
• Arao Y, Kuriyama R, Kayama F, Kato S (2000). "A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D". Arch. Biochem. Biophys. 380 (2): 228–236. doi:10.1006/abbi.2000.1938. PMID 10933876.
• Grosset C, Chen CY, Xu N, Sonenberg N, Jacquemin-Sablon H, Shyu AB (September 2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex". Cell. 103 (1): 29–40. doi:10.1016/S0092-8674(00)00102-1. PMID 11051545. S2CID 18135412.
• Katahira M, Miyanoiri Y, Enokizono Y, Matsuda G, Nagata T, Ishikawa F, Uesugi S (August 2001). "Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA". J. Mol. Biol. 311 (5): 973–88. doi:10.1006/jmbi.2001.4862. PMID 11531333.
• Lapucci A, Donnini M, Papucci L, Witort E, Tempestini A, Bevilacqua A, Nicolin A, Brewer G, Schiavone N, Capaccioli S (May 2002). "AUF1 Is a bcl-2 A + U-rich element-binding protein involved in bcl-2 mRNA destabilization during apoptosis" (PDF). J. Biol. Chem. 277 (18): 16139–46. doi:10.1074/jbc.M201377200. PMID 11856759.
• Tolnay M, Juang YT, Tsokos GC (2002). "Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion". Biochem. J. 363 (Pt 1): 127–36. doi:10.1042/0264-6021:3630127. PMC 1222459. PMID 11903055.
• Pioli PA, Hamilton BJ, Connolly JE, Brewer G, Rigby WF (September 2002). "Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1". J. Biol. Chem. 277 (38): 35738–45. doi:10.1074/jbc.M204002200. PMID 12107167.
• Shchors K, Yehiely F, Kular RK, Kotlo KU, Brewer G, Deiss LP (December 2002). "Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27". J. Biol. Chem. 277 (49): 47061–72. doi:10.1074/jbc.M202272200. PMID 12356764.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Heterogeneous nuclear ribonucleoprotein D0 (HNRPD)

• Genes on human chromosome 4