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HOMER2

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Protein and coding gene in humans
HOMER2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1I7A

Identifiers
AliasesHOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDsOMIM: 604799; MGI: 1347354; HomoloGene: 3560; GeneCards: HOMER2; OMA:HOMER2 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)
Chromosome 15 (human)Genomic location for HOMER2Genomic location for HOMER2
Band15q25.2Start82,836,946 bp
End82,986,153 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for HOMER2Genomic location for HOMER2
Band7|7 D3Start81,250,229 bp
End81,357,275 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • olfactory zone of nasal mucosa

  • muscle of thigh

  • minor salivary glands

  • gastrocnemius muscle

  • islet of Langerhans

  • Skeletal muscle tissue of rectus abdominis

  • skin of leg

  • parotid gland

  • skin of abdomen
Top expressed in
  • lacrimal gland

  • parotid gland

  • transitional epithelium of urinary bladder

  • lateral septal nucleus

  • substantia nigra

  • Region I of hippocampus proper

  • crypt of lieberkuhn of small intestine

  • epithelium of stomach

  • olfactory epithelium

  • trigeminal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9455

26557

Ensembl

ENSG00000103942

ENSMUSG00000025813

UniProt

Q9NSB8

Q9QWW1

RefSeq (mRNA)

NM_004839
NM_199330
NM_199331
NM_199332

NM_001164086
NM_001164087
NM_011983
NM_177029

RefSeq (protein)

NP_004830
NP_955362

NP_001157558
NP_001157559
NP_036113

Location (UCSC)Chr 15: 82.84 – 82.99 MbChr 7: 81.25 – 81.36 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.

Interactions

HOMER2 has been shown to interact with RYR1.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000103942Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025813Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
  6. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
  7. ^ "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
  8. Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47). United States: 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.

Further reading

PDB gallery
  • 1i7a: EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2 1i7a: EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2


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