HSI may refer to:
Government and politics
- Croatian Syrmian Initiative, a political party in Serbia (Croatian: Hrvatska srijemska inicijativa)
- Hispanic-serving institution, an American college designation
- Homeland Security Investigations, an American law enforcement agency
- Humane Society International, an animal welfare organization
Science and technology
- HSI color space, in computing
- Heterosubtypic immunity, in medicine
- High Speed Interconnect, a computer chip
- Horizontal shaft impactor, a rock crusher
- Horizontal situation indicator, an aircraft instrument
- Hurricane Severity Index
- Hyperspectral imaging
Sport
- HSI (track team)
- Croatian World Games (Croatian: Hrvatske svjetske igre), multi-sport international event
- Icelandic Handball Association (Icelandic: Handknattleikssamband Íslands, HSÍ)
Other uses
- Hsi (surname), various Chinese surnames, romanized Xi in Pinyin
- Hang Seng Index, a stock market index
- Hastings Municipal Airport, Nebraska, United States
See also
- HS1 (disambiguation) ('HS' and the digit '1')
- Xi (disambiguation) — Xi and Hsi are different transliterations of the same sound in Chinese
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