HSO may refer to:
Orchestras
- Harrisburg Symphony Orchestra, Pennsylvania, United States
- Hartford Symphony Orchestra, Connecticut, United States
- Helena Symphony Orchestra, Montana, United States
- Hereford String Orchestra, England
- Hillsboro Symphony Orchestra, Oregon, United States
- Hollywood Symphony Orchestra, California, United States
- Houston Symphony, Texas, United States
- Huntsville Symphony Orchestra, Alabama, United States
Other uses
- Ford HSO engine
- Hamburg State Opera
- Health Sciences Online
- Healthscope, an Australian hospital operator
- Herschel Space Observatory
- Hungarian Space Office
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