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HT-2157

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Chemical compound Pharmaceutical compound
HT-2157
Structural formula
Space-filling model
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 1-Phenyl-3-iminoindol-2-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
Chemical and physical data
FormulaC21H13F3N2O
Molar mass366.343 g·mol
3D model (JSmol)
SMILES
  • c14ccccc4n(-c3ccccc3)c(=O)c1=N\c(c2)cccc2C(F)(F)F
InChI
  • InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19+
  • Key:TXCGMRVPXUBHAL-NCELDCMTSA-N

HT-2157 (former development code SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.

References

  1. "pA2 Online". www.pa2online.org.
  2. Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hökfelt T, et al. (November 2005). "Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299". Proceedings of the National Academy of Sciences of the United States of America. 102 (48): 17489–94. doi:10.1073/pnas.0508970102. PMC 1283534. PMID 16287967.
  3. US 8277842, Kaplan AP, "Enteric-coated HT-2157 compositions and methods of their use", published January 20, 2012 
  4. "Dart NeuroScience LLC -- Scientific Advisory Board". www.dartneuroscience.com.


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