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HYAL3
Identifiers
Aliases	HYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3, hyaluronidase 3
External IDs	OMIM: 604038; MGI: 1330288; HomoloGene: 2626; GeneCards: HYAL3; OMA:HYAL3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 50,292,831 bp End 50,299,405 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F1|9 58.19 cM Start 107,458,017 bp End 107,464,558 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad bone marrow prefrontal cortex left testis right hemisphere of cerebellum right testis superior frontal gyrus primary visual cortex right frontal lobe Top expressed in embryo embryo right kidney blastocyst proximal tubule spermatid zygote vestibular membrane of cochlear duct ventricular zone tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity, acting on glycosyl bonds protein binding hyaluronoglucuronidase activity hydrolase activity catalytic activity hyalurononglucosaminidase activity Cellular component extracellular region acrosomal vesicle acrosomal membrane lysosome endosome early endosome endoplasmic reticulum plasma membrane membrane cytoplasmic vesicle sperm midpiece Biological process cellular response to UV-B cartilage development response to antibiotic cellular response to tumor necrosis factor metabolism cellular response to interleukin-1 inflammatory response hyaluronan catabolic process carbohydrate metabolic process response to virus ovarian follicle atresia single fertilization penetration of zona pellucida negative regulation of ovarian follicle development positive regulation of acrosomal vesicle exocytosis viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8372 109685 Ensembl ENSG00000186792 ENSMUSG00000036091 UniProt O43820 Q8VEI3 RefSeq (mRNA) NM_003549 NM_001200029 NM_001200030 NM_001200031 NM_001200032 NM_178020 RefSeq (protein) NP_001186958 NP_001186959 NP_001186960 NP_001186961 NP_003540 NP_821139 Location (UCSC) Chr 3: 50.29 – 50.3 Mb Chr 9: 107.46 – 107.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000186792 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000036091 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61. doi:10.1006/geno.1999.5876. PMID 10493834.
6. ^ "Entrez Gene: HYAL3 hyaluronoglucosaminidase 3".

Further reading

• Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997. S2CID 4413586.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Junker N, Latini S, Petersen LN, Kristjansen PE (2003). "Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncol. Rep. 10 (3): 609–16. doi:10.3892/or.10.3.609 (inactive 1 November 2024). PMID 12684632.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lokeshwar VB, Schroeder GL, Carey RI, et al. (2002). "Regulation of hyaluronidase activity by alternative mRNA splicing". J. Biol. Chem. 277 (37): 33654–63. doi:10.1074/jbc.M203821200. PMID 12084718. S2CID 8385249.
• Shuttleworth TL, Wilson MD, Wicklow BA, et al. (2002). "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3". J. Biol. Chem. 277 (25): 23008–18. doi:10.1074/jbc.M108991200. PMID 11929860. S2CID 24252110.
• Triggs-Raine B, Salo TJ, Zhang H, et al. (1999). "Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6296–300. Bibcode:1999PNAS...96.6296T. doi:10.1073/pnas.96.11.6296. PMC 26875. PMID 10339581.

• Genes on human chromosome 3