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Halimadienyl-diphosphate synthase (EC5.5.1.16, Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)) is an enzyme with systematic namehalima-5,13-dien-15-yl-diphosphate lyase (decyclizing). This enzyme catalyses the following chemical reaction
Nakano C, Okamura T, Sato T, Dairi T, Hoshino T (February 2005). "Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton". Chemical Communications (8): 1016–8. doi:10.1039/b415346d. PMID15719101.