Hamaguchi (written: 浜口 or 濱口) is a Japanese surname. Notable people with the surname include:
- Mark Hamaguchi 浜口マーク (born 1982), Japanese skate boarder
- Hideki Hamaguchi (浜口 秀樹, born 1956), Japanese basketball player
- Honoo Hamaguchi (浜口 炎, born 1971), Japanese basketball coach
- Kanari Hamaguchi (濱口 華菜里, born 1985), Japanese volleyball player
- Masaru Hamaguchi (濱口 優, born 1972), Japanese comedian
- Hamaguchi Osachi (濱口 雄幸, 1870 – 1931), 27th Prime Minister of Japan
- Ryusuke Hamaguchi (濱口 竜介, born 1978), Japanese film director and screenwriter
- Shirō Hamaguchi (浜口 史郎, born 1969), Japanese anime composer
- Sota Hamaguchi (濱口 草太, born 1999), Japanese footballer
- Toshiyuki Hamaguchi (浜口 俊之, born 1970), Japanese motorcycle racer
- Yoshihiro Hamaguchi (浜口 喜博, 1926 – 2011), Japanese freestyle swimmer
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