Hamzić or Hamzic is an South Slavic surname. Notable people with the surname include:
- Amir Hamzić (born 1975), Bosnian footballer
- Armin Hamzic (born 1993), Austrian footballer
- Azra Hamzić (born 1992), Bosnian footballer
- Dino Hamzić (born 1988), Bosnian footballer
- Dževad Hamzić (born 1968), Bosnian volleyball player
- Mihajlo Hamzić (1482–1518), painter from Dubrovnik
- Salko Hamzić (born 2006), Austrian footballer
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