Heffron is a surname. Notable people with the surname include:
- Bob Heffron (1890–1978), politician
- Brian Heffron (born 1973), wrestler and actor
- Edward Heffron (1923–2013), paratrooper
- John Heffron, comic
- Mark Heffron, boxer
- Patrick Richard Heffron (1860–1927), bishop
- Richard T. Heffron (1930–2007), director
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