Hessel is a surname. Notable people with the surname include:
- Bernd Hessel (born 1961), West German sprint canoeist
- Franz Hessel (1880–1941), German author, translator and lecturer
- Katja Hessel (born 1972), German politician
- Lasse Hessel (1940–2019), Danish doctor and inventor
- Johann F. C. Hessel (1796–1872), German physician and mineralogist
- Katja Hessel (born 1972), German politician
- Mats Hessel (born 1961), Swedish ice hockey player
- Phoebe Hessel (1713–1812), woman who disguised herself as a man in order to serve in the British Army
- Stéphane Hessel (1917–2013), French Resistance fighter, diplomat, and writer
See also
- Hessel, a river in Germany
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