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Heterodimeric amino-acid transporter

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Heterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membranes. Each comprises a light and a heavy protein subunit. Transport activity happens in the light.

The following table lists the members of this family:

Transport system Light subunit Heavy subunit Tissue distribution Substrates Affinity Sodium dependence Disease linkage
L LAT1 (SLC7A5) 4F2hc (SLC3A2) kidney, liver, intestine, brain, heart lung, blood–brain barrier large neutral amino acids, thyroid hormones micromolar no –
L LAT2 (SLC7A8) 4F2hc (SLC3A2) kidney, intestine, brain, liver, muscle, heart, lung smaller neutral amino acids millimolar no –
yL yLAT1 (SLC7A7) 4F2hc (SLC3A2) kidney, intestine, lung, erythrocytes, leukocytes large neutral amino acids, dibasic amino acid exchange micromolar yes Lysinuric protein intolerance
yL yLAT2 (SLC7A6) 4F2hc (SLC3A2) brain, intestine, heart, kidney, lung, liver neutral amino acids, dibasic amino acid exchange, glutamine/arginine exchange millimolar yes –
xc xCT (SLC7A11) 4F2hc (SLC3A2) macrophages, liver, kidney, brain glutamine/cystine exchange no –
asc ascAT1 (SLC7A10) 4F2hc (SLC3A2) brain, lung, small intestine, kidney small neutral amino acids no –
b bAT1 (SLC7A9) rBAT (SLC3A1) kidney, intestine, brain neutral/dibasic amino acids no Cystinuria type I

References

  1. Wagner CA, Lang F, Bröer S (October 2001). "Function and structure of heterodimeric amino acid transporters". Am. J. Physiol., Cell Physiol. 281 (4): C1077–93. doi:10.1152/ajpcell.2001.281.4.C1077. PMID 11546643. S2CID 23112134.
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
(1):
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SLC11–20
(11):
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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