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A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.

H₁ agonists promote wakefulness.

H₂: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine.

H₃: Betahistine is a weak Histamine₁ agonist and a very strong antagonist of the Histamine₃ autoreceptor. Antagonizing H₃ increases histaminergic tone.

See also

• Histamine antagonist

References

1. Sakai, N.; Nishino, S. (2013). "Wake-Promoting Medications". Encyclopedia of Sleep. Elsevier. p. 627–633. doi:10.1016/b978-0-12-378610-4.00126-1. ISBN 978-0-12-378611-1. Although centrally injected histamine or histaminergic H1 agonists promote wakefulness, the systemic administration of these compounds induces various unacceptable side effects via peripheral H1 receptor stimulation.

External links

• Histamine+agonist at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• MeSH list of agents 82017442

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