| Histolysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.22.35 | ||||||||
| CAS no. | 92228-52-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Histolysin (EC 3.4.22.35, histolysin, Entamoeba histolytica cysteine proteinase, amebapain, Entamoeba histolytica cysteine protease, Entamoeba histolytica neutral thiol proteinase) is an enzyme. This enzyme catalyses the following chemical reaction
- Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg- in small molecule substrates including Z-Arg-Arg-!NHMec
This enzyme is present in the protozoan, Entamoeba histolytica.
References
- Lushbaugh WB, Hofbauer AF, Pittman FE (June 1985). "Entamoeba histolytica: purification of cathepsin B". Experimental Parasitology. 59 (3): 328–36. doi:10.1016/0014-4894(85)90088-8. PMID 2860002.
- Luaces AL, Barrett AJ (March 1988). "Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica". The Biochemical Journal. 250 (3): 903–9. doi:10.1042/bj2500903. PMC 1148941. PMID 2898937.
External links
- Histolysain at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Proteases: cysteine proteases (EC 3.4.22) | |
|---|---|
| Caspase | |
| Fruit-derived | |
| Calpain | |
| Cathepsin | |
| Other | |
| Enzymes | |
|---|---|
| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
| Types |
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