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Homothorax (HTH or HTX) is a transcriptional co-factor to Hox genes that is closely connected with extradenticle. It may play a role in the identification of segments during panarthropod development. The gene acts in a similar way across the panarthropod phyla, although its expression pattern is reversed in the millipedes, centipedes and crustaceans.

References

1. "Interactive Fly, Drosophila".
2. Moczek, A. P.; Rose, D. J. (2009). "Differential recruitment of limb patterning genes during development and diversification of beetle horns". Proceedings of the National Academy of Sciences. 106 (22): 8992–7. doi:10.1073/pnas.0809668106. PMC 2690047. PMID 19451631.
3. Janssen, R.; Eriksson, B. J.; Budd, G. E.; Akam, M.; Prpic, N. M. (2010). "Gene expression patterns in an onychophoran reveal that regionalization predates limb segmentation in pan-arthropods". Evolution & Development. 12 (4): 363–72. doi:10.1111/j.1525-142X.2010.00423.x. PMID 20618432. S2CID 27770103.

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