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House of Mystery is a series of comics.

House of Mystery may also refer to:

Film

• The House of Mystery (1923 film), a French silent serial film
• The House of Mystery (1933 film), a French crime film
• The House of Mystery (1934 film), an American pre-code mystery horror film directed by William Nigh
• House of Mystery, American alternative title of At the Villa Rosa
• House of Mystery (1961 film), a British supernatural mystery film

Literature

• The House of Mystery, an 1898 novel by Richard Marsh
• The House of Mystery, a 1906 play by Langdon McCormick and a novelization of the play by Grace Miller White
• The House of Mystery, a 1910 novel by Will Irwin
• House of Mystery (Vertigo), an American occult and horror-themed comic book anthology series

Radio

• The House of Mystery (radio series) (1945–1949), an American radio dramatic anthology

• Disambiguation pages