Humphrey Smith is the name of:
Politicians
- Humphrey "Yankee" Smith (1774–1857), unofficial founder of the city of Smithville, Missouri and abolitionist
- Humphrey Smith (MP) (1542–1589), MP for Bodmin
Others
- Humphrey Smith (Quaker) (died 1663), religious writer
- Humphrey Smith Racing, NASCAR racing team
- Humphrey Smith (businessman), owner of Samuel Smith Old Brewery
- Humphrey Smith, fictional character in The Sins of St. Anthony
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