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Idiopathic pneumonia syndrome is a set of pneumonia-like symptoms that occur with no sign of infection in the lung. Idiopathic pneumonia syndrome is a serious condition that can occur after a stem cell transplant. It occurs between 2.2 and 15 percent of hematopoietic stem cell transplants. The incubation period ranges between 4 and 106 days, but mostly is about 22 days from transplant.

Symptoms

The symptoms are like pneumonia, and include fever, chills, coughing, and breathing problems. Lack of oxygen may also occur.

Risk factors

Risk factors for IPS can be old age, graft vs host disease, multi organ failure, and multiple organ failure.

Diagnosis

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Treatment

Treatment is only supportive, with steroids showing no effect. The need for mechanical ventilation is indicative of a poor prognosis. Steroids are often used, though often without effect.

References

1. ^ Klein, Orly; Cooke, Kenneth (2015). "Idiopathic pneumonia syndrome following hematopoietic stem cell transplantation". Journal of Pediatric Intensive Care. 03 (3): 147–157. doi:10.3233/PIC-14098. PMC 6530755. PMID 31214462.

• Idiopathic pneumonia syndrome entry in the public domain NCI Dictionary of Cancer Terms

 This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.

• Pneumonia
• Syndromes affecting the lung