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IHH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3K7G, 3K7H, 3K7I, 3K7J, 3N1F, 3N1M, 3N1O, 3N1P
Identifiers
Aliases	IHH, BDA1, HHG2, indian hedgehog, Indian hedgehog signaling molecule
External IDs	OMIM: 600726; MGI: 96533; HomoloGene: 22586; GeneCards: IHH; OMA:IHH - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 219,054,424 bp End 219,060,921 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C4|1 38.55 cM Start 74,984,474 bp End 74,990,831 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon testicle gonad mucosa of ileum tibia rectum mucosa of sigmoid colon duodenum jejunal mucosa pylorus Top expressed in forearm humerus tibia finger epithelium of stomach epiphyseal plate yolk sac left colon ulna pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding peptidase activity hydrolase activity patched binding protein binding Cellular component membrane plasma membrane extracellular region extracellular space extracellular matrix Biological process response to estradiol maternal process involved in female pregnancy positive regulation of epithelial cell proliferation cell-cell signaling negative regulation of apoptotic process proteolysis multicellular organism development intein-mediated protein splicing smoothened signaling pathway positive regulation of transcription by RNA polymerase II skeletal system development ossification branching involved in blood vessel morphogenesis osteoblast differentiation in utero embryonic development cell fate specification morphogenesis of a branching structure vasculature development heart looping positive regulation of mesenchymal cell proliferation epithelial cell morphogenesis retinal pigment epithelium development chondrocyte differentiation involved in endochondral bone morphogenesis proteoglycan metabolic process pattern specification process positive regulation of cell population proliferation embryonic pattern specification cell differentiation vitelline membrane formation pancreas development positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus positive regulation of T cell differentiation in thymus multicellular organism growth chondrocyte proliferation regulation of growth embryonic digit morphogenesis camera-type eye development bone resorption negative regulation of cell differentiation positive regulation of smoothened signaling pathway positive regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation negative regulation of eye pigmentation cell maturation embryonic digestive tract morphogenesis embryonic camera-type eye morphogenesis neuron development smooth muscle tissue development cartilage development camera-type eye photoreceptor cell fate commitment head morphogenesis somite development embryonic skeletal joint development epithelial cell-cell adhesion response to mechanical stimulus liver regeneration regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3549 16147 Ensembl ENSG00000163501 ENSMUSG00000006538 UniProt Q14623 P97812 RefSeq (mRNA) NM_002181 NM_010544 NM_001313683 RefSeq (protein) NP_002172 NP_001300612 NP_034674 Location (UCSC) Chr 2: 219.05 – 219.06 Mb Chr 1: 74.98 – 74.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Indian hedgehog homolog (Drosophila), also known as IHH, is a protein which in humans is encoded by the IHH gene. This cell signaling protein is in the hedgehog signaling pathway. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the Indian hedgehog is honored by this one. The gene is not specific to Indian hedgehogs.

Function

The Indian hedgehog protein is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog (DHH) and sonic hedgehog (SHH). It is involved in chondrocyte differentiation, proliferation and maturation especially during endochondral ossification. It regulates its effects by feedback control of parathyroid hormone-related peptide (PTHrP).

Indian Hedge Hog, (Ihh) is one of three signaling molecules from the Hedgehog (Hh) gene family. Genes of the Hh family, Sonic Hedgehog (Shh), Desert Hedgehog (Dhh) and Ihh regulate several fetal developmental processes. The Ihh homolog is involved in the formation of chondrocytes during the development of limbs. The protein is released by small, non-proliferating, mature chondrocytes during endochondral ossification. Recently, Ihh mutations are shown to cause brachydactyly type A1 (BDA1), the first Mendelian autosomal dominant disorder in humans to be recorded. There are seven known mutations to Ihh that cause BDA1. Of particular interest, are mutations involving the E95 residue, which is thought to be involved with proper signaling mechanisms between Ihh and its receptors. In a mouse model, mice with mutations to the E95 residue were found to have abnormalities to their digits.

Ihh may also be involved in endometrial cell differentiation and implantation. Studies have shown progesterone to upregulate Ihh expression in the murine endometrium, suggesting a role in implantation. Ihh is suspected to be involved in the downstream regulation of other signaling molecules that are known to play a role in murine implantation. Mouse models involving Ihh null mice demonstrated failure of attachment and decidualization.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000163501 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000006538 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IHH Indian hedgehog homolog (Drosophila)".
6. Marigo V, Roberts DJ, Lee SM, Tsukurov O, Levi T, Gastier JM, Epstein DJ, Gilbert DJ, Copeland NG, Seidman CE (July 1995). "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog". Genomics. 28 (1): 44–51. doi:10.1006/geno.1995.1104. PMID 7590746.
7. van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, Nielsen C, Gaffield W, van Deventer SJ, Roberts DJ, Peppelenbosch MP (March 2004). "Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation". Nat. Genet. 36 (3): 277–82. doi:10.1038/ng1304. PMID 14770182.
8. Kumar S, Balczarek KA, Lai ZC (March 1996). "Evolution of the hedgehog gene family". Genetics. 142 (3): 965–72. doi:10.1093/genetics/142.3.965. PMC 1207033. PMID 8849902.
9. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ (August 1996). "Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein". Science. 273 (5275): 613–22. Bibcode:1996Sci...273..613V. doi:10.1126/science.273.5275.613. PMID 8662546. S2CID 27737023.
10. ^ Ma, G., Yu, J., Xiao, Y. et al. Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Res 21, 1343–1357 (2011). https://doi.org/10.1038/cr.2011.76
11. ^ Lodder EM, Hoogeboom AJM, Coert JH, de Graaff E. 2008. Deletion of 1 amino acid in Indian hedgehog leads to brachydactylyA1. Am J Med Genet Part A 146A:2152–2154. doi:10.1002/ajmg.a.32441
12. Gao, B., Hu, J., Stricker, S. et al. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 458, 1196–1200 (2009). https://doi.org/10.1038/nature07862
13. Qingxiang Wei, Eric D. Levens, Lilja Stefansson, Lynnette K. Nieman, Indian Hedgehog and Its Targets in Human Endometrium: Menstrual Cycle Expression and Response to CDB-2914, The Journal of Clinical Endocrinology & Metabolism, Volume 95, Issue 12, 1 December 2010, Pages 5330–5337, https://doi.org/10.1210/jc.2010-0637
14. ^ Kathryn Smith, Redab Alnifaidy, Qingxiang Wei, Lynnette K. Nieman, Endometrial Indian hedgehog expression is decreased in women with endometriosis, Fertility and Sterility, Volume 95, Issue 8, 2011, Pages 2738-2741.e3, ISSN 0015-0282, https://doi.org/10.1016/j.fertnstert.2011.05.018.

Further reading

• St-Jacques B, Hammerschmidt M, McMahon AP (August 1999). "Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation". Genes Dev. 13 (16): 2072–86. doi:10.1101/gad.13.16.2072. PMC 316949. PMID 10465785.
• Karp SJ, Schipani E, St-Jacques B, Hunzelman J, Kronenberg H, McMahon AP (February 2000). "Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways". Development. 127 (3): 543–8. doi:10.1242/dev.127.3.543. PMID 10631175.
• Minina E, Wenzel HM, Kreschel C, Karp S, Gaffield W, McMahon AP, Vortkamp A (November 2001). "BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation". Development. 128 (22): 4523–34. doi:10.1242/dev.128.22.4523. PMID 11714677.
• Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ (August 1996). "Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein". Science. 273 (5275): 613–22. Bibcode:1996Sci...273..613V. doi:10.1126/science.273.5275.613. PMID 8662546. S2CID 27737023.
• Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ (September 2003). "ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development". J. Bone Miner. Res. 18 (9): 1593–604. doi:10.1359/jbmr.2003.18.9.1593. PMID 12968668. S2CID 24537500.
• Long F, Zhang XM, Karp S, Yang Y, McMahon AP (December 2001). "Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation". Development. 128 (24): 5099–108. doi:10.1242/dev.128.24.5099. PMID 11748145.
• Marigo V, Roberts DJ, Lee SM, et al. (1995). "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog". Genomics. 28 (1): 44–51. doi:10.1006/geno.1995.1104. PMID 7590746.
• Chang DT, López A, von Kessler DP, et al. (1995). "Products, genetic linkage and limb patterning activity of a murine hedgehog gene". Development. 120 (11): 3339–53. doi:10.1242/dev.120.11.3339. PMID 7720571.
• Porter JA, Young KE, Beachy PA (1996). "Cholesterol modification of hedgehog signaling proteins in animal development". Science. 274 (5285): 255–9. Bibcode:1996Sci...274..255P. doi:10.1126/science.274.5285.255. PMID 8824192. S2CID 11125394.
• Leek JP, Moynihan TP, Anwar R, et al. (1997). "Assignment of Indian hedgehog (IHH) to human chromosome bands 2q33→q35 by in situ hybridization". Cytogenet. Cell Genet. 76 (3–4): 187–8. doi:10.1159/000134545. PMID 9186520.
• Pepinsky RB, Zeng C, Wen D, et al. (1998). "Identification of a palmitic acid-modified form of human Sonic hedgehog". J. Biol. Chem. 273 (22): 14037–45. doi:10.1074/jbc.273.22.14037. PMID 9593755.
• Carpenter D, Stone DM, Brush J, et al. (1998). "Characterization of two patched receptors for the vertebrate hedgehog protein family". Proc. Natl. Acad. Sci. U.S.A. 95 (23): 13630–4. Bibcode:1998PNAS...9513630C. doi:10.1073/pnas.95.23.13630. PMC 24870. PMID 9811851.
• Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein". Nature. 397 (6720): 617–21. Bibcode:1999Natur.397..617C. doi:10.1038/17611. PMID 10050855. S2CID 204991314.
• Ito H, Akiyama H, Shigeno C, et al. (1999). "Hedgehog signaling molecules in bone marrow cells at the initial stage of fracture repair". Biochem. Biophys. Res. Commun. 262 (2): 443–51. doi:10.1006/bbrc.1999.1197. PMID 10462495.
• Bak M, Hansen C, Friis Henriksen K, Tommerup N (2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". Cytogenet. Cell Genet. 92 (3–4): 300–3. doi:10.1159/000056918. PMID 11435703. S2CID 32938414.
• Gao B, Guo J, She C, et al. (2001). "Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1". Nat. Genet. 28 (4): 386–8. doi:10.1038/ng577. PMID 11455389. S2CID 22572955.
• Gritli-Linde A, Lewis P, McMahon AP, Linde A (2001). "The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides". Dev. Biol. 236 (2): 364–86. doi:10.1006/dbio.2001.0336. PMID 11476578.
• Kindblom JM, Nilsson O, Hurme T, et al. (2002). "Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development". J. Endocrinol. 174 (2): R1–6. doi:10.1677/joe.0.174R001. PMID 12176676.
• Cormier S, Delezoide AL, Benoist-Lasselin C, et al. (2002). "Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations". Am. J. Pathol. 161 (4): 1325–35. doi:10.1016/s0002-9440(10)64409-4. PMC 1867304. PMID 12368206.
• McCready ME, Sweeney E, Fryer AE, et al. (2002). "A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved". Hum. Genet. 111 (4–5): 368–75. doi:10.1007/s00439-002-0815-2. PMID 12384778. S2CID 36346206.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kirkpatrick TJ, Au KS, Mastrobattista JM, et al. (2003). "Identification of a mutation in the Indian Hedgehog (IHH) gene causing brachydactyly type A1 and evidence for a third locus". J. Med. Genet. 40 (1): 42–4. doi:10.1136/jmg.40.1.42. PMC 1735266. PMID 12525541.
• Hellemans J, Coucke PJ, Giedion A, et al. (2003). "Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips". Am. J. Hum. Genet. 72 (4): 1040–6. doi:10.1086/374318. PMC 1180335. PMID 12632327.
• Niemann C, Unden AB, Lyle S, et al. (2003). "Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis". Proc. Natl. Acad. Sci. U.S.A. 100 (Suppl 1): 11873–80. Bibcode:2003PNAS..10011873N. doi:10.1073/pnas.1834202100. PMC 304101. PMID 12917489.
• Berman DM, Karhadkar SS, Maitra A, et al. (2003). "Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours". Nature. 425 (6960): 846–51. Bibcode:2003Natur.425..846B. doi:10.1038/nature01972. PMID 14520411. S2CID 2877022.
• Garcia-Barceló MM, Lee WS, Sham MH, et al. (2004). "Is there a role for the IHH gene in Hirschsprung's disease?". Neurogastroenterol. Motil. 15 (6): 663–8. doi:10.1046/j.1350-1925.2003.00447.x. PMID 14651602. S2CID 20918822.

• Genes on human chromosome 2
• Proteins
• Morphogens