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Influenza non-structural protein

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Protein family
Influenza non-structural protein (NS1)
Identifiers
SymbolFlu_NS1
PfamPF00600
InterProIPR000256
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDBPDB: 1ail​ PDB: 1ns1​

Influenza non-structural protein (NS1) is a homodimeric RNA-binding protein found in influenza virus that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA.

References

  1. Huang Y, Rios CB, Tejero R, Zimmerman DE, Krug RM, Montelione GT, Chien CY (1997). "A novel RNA-binding motif in influenza A virus non-structural protein 1". Nat. Struct. Biol. 4 (11): 891–895. doi:10.1038/nsb1197-891. PMID 9360601. S2CID 10671571.
This article incorporates text from the public domain Pfam and InterPro: IPR000256 Category: