Ishkashim, also transliterated Eshkashem or Ishkoshim, may refer to:
- Ishkashim, Afghanistan, a town in Badakhshan Province
- Ishkashim, Tajikistan, a town in Gorno-Badakshan Autonomous Province
- Ishkashim District in Badakhshan Province of Afghanistan
- Ishkashim District in Gorno-Badakhshan Autonomous Province
- Ishkashimi language, spoken in Afghanistan and Tajikistan
- Ishkashimi people [ru]
- Ishkoshim Range, mountain range in Pamir Mountains in Tajikistan
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